Publications

For a complete publication list, see Pubmed

Preprints from the Lesch Lab:

Marshall KL, Stadtmauer DJ, Maziarz J, Wagner GP, Lesch BJ. Evolutionary innovations in germline biology of placental mammals revealed by transcriptomics of first wave spermatogenesis in opossum. bioRxiv 2023.06.17.545442. link

 

Publications from the Lesch Lab:

Walters BW, Rainsford SR, Heuer RA, Dias N, Huang X, de Rooij D, Lesch BJ. KDM6A/UTX promotes spermatogenic gene expression across generations and is not required for male fertility. Biol Reprod. 2023 Oct 20:ioad141. link

Malla AB, Yu H, Farris D, Kadimi S, Lam TT, Cox AL, Smith ZD, Lesch BJ. DOT1L bridges transcription and heterochromatin formation at mammalian pericentromeres EMBO Rep. 2023;e56492. link

Malla AB, Rainsford SR, Smith ZD, Lesch BJ. DOT1L promotes spermatid differentiation by regulating expression of genes required for histone-to-protamine replacement. Development 2023, 150:9. dev201497. link

Griffin KN, Walters BW, Li H, Wang H, Biancon G, Tebaldi T, Kaya CB, Kanyo J, Lam TT, Cox AL, Halene S, Chung JJ, Lesch BJ. Widespread association of the Argonaute protein AGO2 with meiotic chromatin suggests a distinct nuclear function in mammalian male reproduction. Genome Research 2022 Sep 15;32(9):1655–68. co-first author link

Bae S, Lesch BJ. H3K4me1 Distribution Predicts Transcription State and Poising at Promoters. Front Cell Dev Biol. 2020 May 5;8:289. link

Lesch BJ, Tothova Z, Morgan EA, Liao Z, Bronson RT, Ebert BL, Page DC*. Intergenerational epigenetic inheritance of cancer susceptibility in mammals. Elife. 2019 Apr 9;8:e39380.   link  news article in The Scientist magazine

Lesch BJ, Silber SJ, McCarrey JR, Page DC. Parallel evolution of male germline epigenetic poising and somatic development in animals. Nature Genetics. 2016 Aug;48(8):888-94.  link  comment

Lesch BJ, Page DC. Poised chromatin in the mammalian germ line. Development. 2014 Oct;141(19):3619-26. link

Alpatov R, Lesch BJ, Nakamoto-Kinoshita M, et al. A chromatin-dependent role of the fragile X mental retardation protein FMRP in the DNA damage response. Cell. 2014;157(4):869-881. *co-first  link 

Lesch BJ, Dokshin GA, Young RA, McCarrey JR, Page DC. A set of genes critical to development is epigenetically poised in mouse germ cells from fetal stages through completion of meiosis. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16061-6. link  comment 1  comment 2

Okumura LM, Lesch BJ, Page DC. The ligand binding domain of GCNF is not required for repression of pluripotency genes in mouse fetal ovarian germ cells. PLoS One. 2013 Jun 7;8(6):e66062. *co-corresponding  link 

Lesch BJ, Page DC. Genetics of germ cell development. Nat Rev Genet. 2012 Nov;13(11):781-94. link 

 

Other publications:

Biancon G, Busarello E, Joshi P, Lesch BJ, Halene S, Tebaldi T. Fractionated eCLIP-seq (freCLIP-seq) to deconvolve in vivo protein-RNA contacts. STAR Protocols 2022 Dec 16;3(4):101823. link

Chandrasekaran S, Espeso-Gil S, Loh Y-HE, Javidfar B, Kassim B, Dong Y, ZhuY, Bicks LK, Li H, Rajarajan P, Peter CJ, Agullo-Pascual E, Iskhakova M, Estill M, Lesch BJ, Shen L, Jiang Y, Akbarian S. Neuron-specific chromosomal megadomain organization is adaptive to recent retrotransposon expansions. Nature Communications 2021 Dec 13;12(1):7243. link

Alqadah A, Hsieh YW, Xiong R, Lesch BJ, Chang C, Chuang CF. A universal transportin protein drives stochastic choice of olfactory neurons via specific nuclear import of a sox-2-activating factor. Proc Natl Acad Sci U S A. 2019 Dec 10;116(50):25137-25146. link