Lab News

A QED Science top 1% score (out of 57,455 preprints evaluated) for sperm Fiber-seq!

Welcome to our newest PhD student Stephanie!

Another new preprint! Emerging bivalent domains in the mammalian male germ line are associated with different functions depending on ancestral chromatin state:

Ancestral chromatin state constrains the functional landscape of bivalent domains in mammalian spermatogenesis

New preprint! Evolutionarily recent gain of bivalency in germ cells is associated with immune (not fertility!) phenotypes: 

Complementary constraints in germ and immune cells shape evolution of gene regulation and phenotype

Bluma discusses sperm Fiber-seq at the Fragile Nucleosome seminar - watch it here

We celebrated another highly successful thesis defense. Huge congratulations to Dr. Haoming Yu! 

New preprint! In an outstanding collaboration with the Stergachis lab at UW and Tommy Tullius at Princeton, we applied Fiber-seq to get a single-molecule glimpse of the nucleosome-protamine landscape in human sperm: 

Protamine lacunae preserve the paternal chromatin landscape in sperm

Shannon defended her thesis - congratulations Dr. Rainsford!

Check out two new papers out from the lab:

In PNAS:

SMARCA5 restricts chromatin accessibility to promote male meiosis and fertility in mammals

In Genes & Development:

H3K4me3 amplifies transcription at intergenic active regulatory elements

Congratulations all!!!

Five years and one day after she joined the lab, we celebrated Dr. Kira Marshall's thesis defense. Op-awesome!